Homo sapiens were wandering out of Africa at least 177,000 years ago — some 60,000 years earlier than previously thought.
The new migration date comes after ancient stone tools and part of a fossilised Homo sapiens jaw bone with teeth were discovered in a cave in northern Israel.
Until now, the oldest evidence for modern humans outside Africa were only 90,000 to 120,000 years old.
Homo sapiens first appeared in Africa, with the earliest-known fossils roughly 300,000 years old. A key milestone was when our species first ventured out of Africa en route to populating the far corners of the globe.
The teeth are in the upper size range of what's seen in modern humans
The fossil jaw and tools, presented today in the journal Science, challenges currently accepted ideas about how modern humans dispersed from Africa, according to Peter Hiscock, an archaeologist at the University of Sydney.
• Oldest evidence for Homo sapiens outside Africa was found in a cave in Israel
• A partial jaw bone, teeth and stone tools were dated to around 180,000 years old
While geneticists have traced the modern human's emergence from Africa back around 60,000 to 80,000 years, "skeletal information excavated by archaeologists has told a much older story", Professor Hiscock said.
Misliya Cave is located 90m above mean sea level
Caves in the north of Israel have yielded many old hominid fossils and artefacts, including the previously oldest known Homo sapiens fossils outside Africa.
In 2001, Hershkovitz from the University of Tel Aviv and his colleagues began excavating the Misliya Cave, near Mount Carmel.
It didn't take long to strike gold. In 2002, a student found a partial jaw bone.
It comprised part of the upper jaw, including teeth, part of the cheekbone and roof of the mouth.
Professor Hershkovitz and his team examined the fossil's anatomy to ascertain what species it belonged to.
While it shared some similarities with other hominid specimens such as Neanderthals, it seemed to fall in the Homo sapiens camp.
The teeth were large, for instance, but fit within the normal range of a modern human's chompers.
If the teeth belonged to a Neanderthal or an earlier hominid, they should have had broader tooth crowns or a different pattern of cusps (the bumpy bits on a molar's chewing surface).
How to date a hominidAfter establishing the jaw-owner's species, it was time to find out how old it was.
To triple check, the researchers enlisted help from three independent dating labs.
Rainer Gruen, who was then at the Australian National University, was sent a "teeny, tiny bit of the tooth".
Professor Gruen used a minimally destructive technique that "uses a quite large laser to burn tiny holes" to date the sample.
Two other labs dated the age of the sediment crust clinging to the fossil and burnt tools found nearby.
They all yielded estimations that were roughly the same: around 177,000 years old, give or take 20,000 years or so.
The owner of the jaw bone wasn't necessarily part of the modern human population that went on to populate the world, said Professor Hiscock.
They may have moved back to Africa. Or maybe they died out.
Perhaps, he added, our ancestors acquired cultural characteristics in Africa that allowed them to colonise the globe that these early modern humans didn't have.
Tools found near the jaw bone, in Misliya Cave, also add to the story.
The style of stone tool, called Levallois, is a very economical way of making tools, said University of New South Wales palaeontologist Darren Curnoe.
Levallois tools have been uncovered in Europe that are almost 300,000 years old.
It was assumed they were made by Neanderthals, because modern humans didn't make it that far until around 50,000 years ago, Dr Curnoe said.